Nancy A. Klein, MD

Specialties-Reproductive Endocrinology & Infertility:

• Assisted reproductive technologies, IVF
• Age-related infertility and egg donation
• Anovulation, irregular menstruation and ovulation induction with injections and oral fertility drugs, such as Clomid

Licensure:

• Washington, 1993

• Obstetrics and Gynecology, 1995
• Reproductive Endocrinology and Infertility, 1998

• MD degree (Vanderbilt University Medical School, 1985)
• Residency in Obstetrics and Gynecology (University of Tennessee, 1990)
• Fellowship in Reproductive Endocrinology and Infertility (University of Texas, 1993)

• Reproductive aging
• Assisted Reproductive Technologies (ART)
• Aging of the Normal Human Ovary from Birth to Menopause

• American College of Obstetricians and Gynecologists
• American Society for Reproductive Medicine
• Society for Assisted Reproductive Technologies
• Pacific Coast Reproductive Society
• Society for Gynecologic Investigation
• Society of Reproductive Endocrinology and Infertility

Honors

• Past NIH grant recipient
• ASRM prize paper recipient 2003, 2006
• Seattle Magazine Top Doctors for Women 2003
• Seattle Magaine Top Doctors 2006, 2007
• Seattle Metropolitan Magazine Top Doctors 2007

Publications:

Klein NA, Battaglia DE, Clifton DK, Bremner WJ, Soules MR. The gonadotropin secretion pattern in normal women of advanced reproductive age in relation to the monotropic FSH rise. J Soc Gynecol Invest 1996;3:27-32.

Fujimoto VY, Klein NA, Davis GS, Bremner WJ, Soules MR. Attenuated release of pituitary luteinizing hormone in older reproductive-age women in response to GnRH stimulation. Fertil Steril 1996;65:539-544.

Klein NA, Battaglia DE, Fujimoto VY, Clifton DK, Davis GS, Bremner WJ, Soules MR. Reproductive aging: accelerated ovarian follicular development associated with the monotropic FSH rise in normal older women. J Clin Endocrinol Metab 1996;81:1038-1045.

Klein NA, Battaglia DE, Miller PB, Soules MR. Circulating levels of growth hormone, IGF-I, and growth hormone binding protein in normal women of advanced reproductive age. Clin Endo 1996; 44:285-292.

Klein NA, Battaglia DE, Miller PB, Giudice LC, Soules MR. Ovarian follicular development and the follicular fluid hormones and growth factors in normal women of advanced reproductive age. J Clin Endocrinol Metab 1996;81:1946-51.

Klein NA, Illingworth PJ, Groome NP, McNeilly AS, Battaglia DE, Soules MR. Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles. J Clin Endocrinol Metab 1996;81:2742-2745.

Battaglia DE, Goodwin P, Klein NA, Soules MR. Influence of maternal age on meiotic spindle assembly in the human oocyte. Human Reprod 1996;11:2217.

Battaglia DE, Klein NA, Soules MR. Changes in centrosomal domains during meiotic maturation in the human oocyte. Molecular Hum Reprod 1997;2:845-851.

Klein NA, Battaglia DE, Woodruff TK, Padmanabhan V, Giudice LC, Groome NP, Bremner WJ, Soules MR. Ovarian follicular concentrations of follistatin, inhibin, IGF-I, IGF-II, IGFBP-2, IGFBP-3, and VEGF in spontaneous menstrual cycles of normal women of advanced reproductive age. J Clin Endocrinol Metab, 2000;85:4520-4525.

Klein NA, Harper AJ, Houmard BS, Soules MS. Is the short follicular phase in older women secondary to advanced or accelerated dominant follicle development? J Clin Endocrinol Metab, in press.

Revised May 15, 2007